how to read a tempus report

3 min read 16-01-2025

Understanding your Tempus report can feel overwhelming. This comprehensive guide breaks down how to interpret the key sections, empowering you to understand your genomic data and its implications for your health. We'll cover everything from navigating the interface to deciphering the results. This guide focuses on understanding your report, not on medical interpretation, which should always be done by a qualified healthcare professional.

Understanding the Tempus Platform

Before diving into your report, it's helpful to understand the Tempus platform itself. Tempus is a healthcare technology company that uses artificial intelligence and machine learning to analyze genomic data. Their reports are comprehensive, often including information beyond just the genetic mutations found.

The Tempus platform generally presents your data in a clear, organized manner, often utilizing visuals like charts and graphs alongside textual explanations. However, the specific layout might vary depending on the type of test performed and the version of the software.

Key Sections of a Tempus Report

A typical Tempus report contains several key sections:

1. Patient Information

This section contains basic identifying information about the patient, such as name, date of birth, and medical record number. This ensures the accuracy and confidentiality of your data.

2. Test Information

This section details the specific genomic test performed (e.g., whole genome sequencing, targeted panel), the date the test was performed, and the laboratory that processed the sample. This provides context for interpreting the results.

3. Summary of Findings

This section provides a high-level overview of significant findings. This is often the first place to look for key results and potential actionable insights. It highlights significant alterations identified in your DNA, summarizing their potential clinical significance.

4. Detailed Variant Report

This section contains the core of the report, detailing each genetic variant identified. Each variant will usually include:

Gene: The specific gene affected.
Variant Type: The type of genetic change (e.g., substitution, insertion, deletion).
Location: The precise location of the variant within the gene.
Classification: How the variant is classified (e.g., benign, likely benign, variant of uncertain significance (VUS), likely pathogenic, pathogenic). This is crucial for understanding potential clinical implications. A pathogenic variant is strongly associated with a disease, while a benign variant is not. VUS requires further investigation.
Evidence: Supporting evidence for the classification, often including references to scientific databases and publications. This information adds credibility to the classifications provided.
Clinical Significance: Explanation of the potential implications of the variant for your health. This section may include information about associated diseases or conditions. This should not be interpreted independently, but rather discussed with your physician.

5. Tumor Mutation Burden (TMB) (If Applicable)

If a tumor sample was analyzed, the report might include TMB. TMB represents the total number of mutations in a tumor sample. High TMB is often associated with a better response to immunotherapy. The report will usually provide the TMB value and its clinical implications.

6. Microsatellite Instability (MSI) (If Applicable)

Similar to TMB, MSI is relevant for tumor samples. MSI refers to errors in DNA replication that can lead to increased mutation rates. High MSI is often associated with a better response to immunotherapy.

7. Pharmacogenomics (If Applicable)

This section, if included, analyzes your genes’ influence on your response to specific medications. This information can help personalize your treatment plan. A physician will be necessary to interpret this information in relation to specific drugs.

8. Ancestry Information (If Applicable)

Some Tempus tests may include ancestry information, providing insights into your genetic background.

Interpreting the Report: Crucial Considerations

This is not a standalone diagnosis. Always discuss your report with your oncologist or a qualified healthcare professional. They can interpret the results in the context of your medical history and current health status.
Focus on the classification of variants. Pay close attention to whether a variant is classified as benign, pathogenic, or VUS. VUS requires further investigation.
Understand the evidence presented. The report should provide evidence for the classification of each variant.
Don't be afraid to ask questions. If anything is unclear, consult your doctor or genetic counselor for clarification. They can explain complex aspects of the report in a way you understand.

Utilizing Your Tempus Report for Optimal Healthcare

Your Tempus report is a powerful tool. By understanding its various sections and collaborating with your healthcare team, you can leverage this information to make informed decisions about your health and treatment. Remember to always prioritize a conversation with your doctor or genetic counselor for personalized interpretation and guidance. This information should complement, not replace, professional medical advice.