how long does nexgard combo take to work

2 min read 02-02-2025

How Long Does NexGard Combo Take to Work? Protecting Your Pet from Fleas and Ticks

NexGard Combo is a popular choice for pet owners seeking comprehensive protection against fleas and ticks. But a common question arises: how quickly does it start working? Understanding the timeframe for NexGard Combo's effectiveness is crucial for ensuring your furry friend remains protected. This article will explore the onset of action, duration of protection, and other important considerations.

Understanding NexGard Combo's Mechanism

NexGard Combo is a chewable tablet containing two active ingredients: afoxolaner (for flea and tick control) and milbemycin oxime (for heartworm, roundworm, hookworm, and whipworm prevention). It works by targeting the nervous system of fleas and ticks, leading to their paralysis and death. The effect on internal parasites is slightly different, with milbemycin oxime impacting their neuromuscular function.

How Quickly Does NexGard Combo Start Working?

For Fleas: NexGard Combo typically starts killing fleas within 30 minutes of administration. You'll likely see a significant reduction in flea activity within a few hours. However, complete elimination of an existing flea infestation may take a few days, as the medication needs to work its way through the flea life cycle.

For Ticks: The onset of action against ticks is slightly slower. NexGard Combo usually begins killing ticks within 4–8 hours of administration. Similar to fleas, total eradication of a tick infestation takes time, depending on the severity.

Important Note: While NexGard Combo rapidly affects existing parasites, it doesn't provide immediate protection against new infestations. The medication builds up a protective layer over time.

Duration of Protection

NexGard Combo provides a full month of protection against fleas and ticks. It's crucial to administer the medication monthly, as scheduled, to maintain continuous coverage. Failure to do so leaves your pet vulnerable to infestations.

Factors Affecting Effectiveness

Several factors can influence how effectively NexGard Combo works:

Pet's Metabolism: Individual metabolic rates vary, influencing the speed of absorption and effectiveness of the medication.
Parasite Load: A heavy infestation may take longer to clear completely.
Environmental Factors: The number of fleas and ticks in your pet's environment plays a significant role. Consistent use of preventative measures is key.
Medication Adherence: Strict adherence to the monthly dosage schedule is essential for continuous protection.

What to Expect After Administration

After giving your pet NexGard Combo, you may not see immediate visible changes. However, you should notice a gradual reduction in flea and tick activity over the following days. If you continue to see a significant number of fleas or ticks after a few days, or if your pet shows signs of distress (vomiting, diarrhea, lethargy), contact your veterinarian immediately.

When to Consult Your Veterinarian

Consult your veterinarian immediately if:

Your pet shows signs of an allergic reaction (itching, hives, swelling).
You notice any unusual symptoms after administering NexGard Combo.
Your pet's flea or tick infestation doesn't improve despite using the medication.

Remember: NexGard Combo is a preventative medication, not a cure-all. Maintaining a clean environment and using additional flea and tick control measures can enhance its effectiveness.

Conclusion: Consistent Protection is Key

While NexGard Combo starts working relatively quickly, complete eradication of existing infestations and ongoing protection require consistent monthly administration. Remember to consult your veterinarian for personalized advice on flea and tick prevention for your pet. They can help determine the best course of action based on your pet's individual needs and your geographic location.

how long does nexgard combo take to work